期刊
FEBS LETTERS
卷 579, 期 4, 页码 873-876出版社
WILEY
DOI: 10.1016/j.febslet.2004.11.029
关键词
DNA polymerase; PCNA; UV light; xeroderma pigmentosum
Most types of DNA damage block the passage of the replication machinery. In order to bypass these blocks, cells employ special translesion synthesis (TLS) DNA polymerases, which have lower stringency than replicative polymerases. DNA polymerase eta is the major polymerase responsible for bypassing UV lesions in DNA and its absence results in the variant form of the genetic disorder, xeroderma pigmentosum. Other TLS polymerases have specificities for different types of damage, but their precise roles inside the cell have not yet been established. These polymerases are located in replication factories during DNA replication and the polymerase sliding clamp PCNA plays an important role in mediating switching between different polymerases. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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