期刊
FEBS LETTERS
卷 579, 期 4, 页码 863-867出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2004.11.038
关键词
DNA sliding clamp; clamp loader; AAA plus ATPase; primer-template junction; DNA replication
资金
- NIGMS NIH HHS [GM38839, F32 GM066586, F32 GM066586-02, F32 GM066586-01, GM45547] Funding Source: Medline
Clamp loaders are heteropentameric ATPase assemblies that load sliding clamps onto DNA and are critical for processive DNA replication. The DNA targets for clamp loading are double-stranded/single-stranded junctions with recessed 3' ends (primer-template junctions). Here, we briefly review the crystal structures of clamp loader complexes and the insights they have provided into the mechanism of the clamp loading process. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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