期刊
FEBS LETTERS
卷 579, 期 5, 页码 1109-1116出版社
WILEY
DOI: 10.1016/j.febslet.2004.12.083
关键词
mitochondria; mtDNA; GTPase; dynamin; yeast; optic atrophy
Mitochondrial morphology is controlled by large GTPases, such as Msp1p, whose action on mitochondrial membranes is not yet understood. The sub-mitochondrial localization of Msp1p, the subject of ongoing controversies, was found to be within the intermembrane space. Overexpression of Msp1p led to aggregation of the mitochondrial network, while its downregulation resulted in fragmentation of this network. Mutations affecting the integrity of the Msp1p GTPase function had a dominant phenotype and induced mitochondrial fragmentation followed by mitochondrial DNA loss and cell death. These effects were not observed in cells deleted for Dnm1p, an actor in mitochondrial fission, suggesting that Msp1p is involved in the fusion of mitochondria. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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