期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 15, 期 4, 页码 945-949出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.12.047
关键词
metabotropic; mGluR5; MPEP; antagonist
资金
- NIDA NIH HHS [DA16180-01] Funding Source: Medline
- NIMH NIH HHS [KO2MH01366, N01MH80005] Funding Source: Medline
We described the synthesis and biological evaluation of MPEP analogs functionalized at the position 3 of the phenyl ring. The results point out the limitation in the choice of a functional group at this position; the only substituents leading to retention of activity are NO2 (IC50 = 13 nM) and CN (IC50 = 8 nM). (C) 2004 Elsevier Ltd. All rights reserved.
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