期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
卷 363, 期 1827, 页码 331-355出版社
ROYAL SOC
DOI: 10.1098/rsta.2004.1496
关键词
biomolecular motors; GroEL; F1-ATPase; molecular dynamics simulations; chaperones; free-energy simulations
Living cells are a collection of molecular machines which carry out many of the functions essential for the cell's existence, differentiation and reproduction. Most, though not all, of these machines are made up of proteins. Because of their complexity, an understanding of how they work requires a synergistic combination of experimental and theoretical studies. In this paper we outline our studies of two such protein machines. One is GroEL, the chaperone from Escherichia coli, which aids in protein folding; the other is F-1-ATPase, a motor protein which synthesizes and hydrolyses ATP.
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