Electrochemical and chemiluminescent immunosensors for tumor markers

The determination of serum tumor markers plays an important role in clinical diagnoses for the patients with certain tumor-associated disease. Although many commercial kits have been applied in clinical immunoassays, conventional methods always have some disadvantages, resulting in the need of other new, efficient, and easily automated methods. Immunosensors, considered as a major development in immunochemical field, have attracted considerable attention. With the aim of rapid screening, many immunosensors that are small, semi-automated and portable are being developed. This brief review focuses on the current research of immunosensors for tumor markers based on the electrochemical and chemiluminescent detection with emphasis on recent advances, challenges, and trends. The works on series of novel immunosensors developed for the determination of tumor markers in our group in the last few years are also introduced. (C) 2004 Elsevier B.V. All rights reserved.