期刊
REGULATORY PEPTIDES
卷 125, 期 1-3, 页码 17-27出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.regpep.2004.07.025
关键词
parathyroid hormone-related protein; LoVo (colon cancer cells); extracellular matrix; proliferation; adhesion; integrins
资金
- NCI NIH HHS [CA83940] Funding Source: Medline
Parathyroid hormone-related protein (PTHrP) has been localized in human colon cancer tissue and cell lines. Tumor cell adhesion to extracellular matrix (ECM) proteins plays a major role in the invasion and metastasis of tumor cells, and is mediated via integrin subunits. The LoVo human colon cancer cell line was used as a model system to study the effects of PTHrP on cell proliferation and adhesion to ECM proteins found in normal liver. Clones of LoVo cells engineered to overexpress PTHrP by stable transfection with a PTHrP cDNA showed enhanced cell proliferation vs. control (empty vector-transfected) cells. PTHrP-overexpressing cells also showed significantly higher adhesion to collagen type I, fibronectin, and laminin, and enhanced expression of the For All2, For All5, For All6, There Exists1 and There Exists4 integrin subunits. These results indicate that PTHrP may play a role in colon cancer invasion and metastasis by increasing cell proliferation and adhesion to the ECM via upregulation of proinvasive integrin expression. (C) 2004 Elsevier B.V. All rights reserved.
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