期刊
COMPUTERS & CHEMICAL ENGINEERING
卷 29, 期 3, 页码 597-617出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compchemeng.2004.08.026
关键词
cyclic route; Petri nets; signalling networks; signalling routes; signal transduction; SigNetRouter
In signalling networks, the presence of multi-part activations/inhibitions and multimolecular reactions results in a highly branched structure. We give a theoretical framework, an algorithm and its implementation - SigNetRouter - for untangling such networks and detecting routes starting with a given initial factor or ending with a desired target. The effects and reactions are here considered as irreversible. If all effects involved in the route are known qualitatively (activation versus inhibition) and both effects and reactions are monomolecular, we can deduce the total effect. The factors acting together and the targets affected on the same route are detected. The cycles and possibly missing reactions are determined. The minimal amounts of each metabolite (in numbers of molecules) required to move the signal through each route and the remaining number of molecules are reported. Some theoretical and biological examples, such as the B cell antigen receptor signalling network illustrate the concepts. (c) 2004 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据