4.7 Article

Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons

期刊

JOURNAL OF NEUROSCIENCE
卷 25, 期 7, 页码 1750-1760

出版社

SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4217-04.2005

关键词

long-term potentiation; intrinsic excitability; Na(+) channel; NMDA receptors; CaM kinases; protein synthesis

资金

  1. NINDS NIH HHS [NS 39997, NS 37349, R01 NS039997] Funding Source: Medline

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The efficiency of neural circuits is enhanced not only by increasing synaptic strength but also by increasing intrinsic excitability. In contrast to the detailed analysis of long-term potentiation (LTP), less attention has been given to activity-dependent changes in the intrinsic neuronal excitability. By stimulating hippocampal CA1 pyramidal neurons with synaptic inputs correlating with postsynaptic neuronal spikes, we elicited an LTP of intrinsic excitability (LTP-IE) concurring with synaptic LTP. LTP-IE was manifested as a decrease in the action potential threshold that was attributable to a hyperpolarized shift in the activation curve of voltage-gated sodium channels (VGSCs) rather than activity-dependent changes in synaptic inputs or A-type K(+) channels. Cell-attached patch recording of VGSC activities indicated such an activity-dependent change in VGSCs. Induction of LTP-IE was blocked by the NMDA receptor antagonist APV, intracellular BAPTA, the CaM kinase inhibitors KN-62 and autocamtide-2-related inhibitory peptide, and the protein synthesis inhibitors emetine and anisomycin. The results suggest that induction of LTP-IE shares a similar signaling pathway with the late phase of synaptic LTP and requires activation of the NMDA glutamate receptor subtype, Ca(2+) influx, activity of CaM kinase II, and function of the protein synthesis. This new form of hippocampal neuronal plasticity could be a cellular correlate of learning and memory besides synaptic LTP.

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