期刊
JOURNAL OF NEUROSCIENCE
卷 25, 期 7, 页码 1856-1865出版社
SOC NEUROSCIENCE
DOI: 10.1523/jneurosci.5208-04.2005
关键词
retina; patch clamp; sodium channel; EPSC; EPSP; retinal ganglion cell; glutamate receptor
资金
- NEI NIH HHS [EY08922, EY02687, P30 EY002687, R01 EY008922] Funding Source: Medline
Retinal bipolar cells are slow potential neurons that respond to photoreceptor inputs with graded potentials and do not fire action potentials. We found that transient ON bipolar cells recorded in retinal slices possess voltage-gated sodium channels located on either their dendrites or somas. The sodium currents in these neurons did not generate spikes but enhanced voltage responses evoked by visual stimulation, which selectively boosted transmission to transient ganglion cells. In contrast, sodium currents were not found in sustained ON bipolar cells, and light responses in sustained bipolar cells and ganglion cells were not affected by TTX. The presence of sodium channels in transient ON bipolar cells contributed to the separation of transient and sustained signals by selectively enhancing the responses of ON transient ganglion cells to light. Our results suggest that bipolar cell sodium channels augment transient signals and contribute to the temporal segregation of visual information.
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