期刊
ONCOGENE
卷 24, 期 8, 页码 1375-1384出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1208301
关键词
c-Myb; B-Myb; transcription; hematopoiesis; T cell
Hematopoiesis, the process by which mature blood cells arise, is controlled by multiple transcription factors, which act in stage- and lineage-specific complexes. It is a major goal to elucidate the genes regulated by these transcription factors, in order to obtain a full understanding of the process and its malignant counterpart, leukemia. Myb family transcription factors play a central role in hematopoicsis. To identify new Myb family target genes, we have used an inducible dominant-negative protein for a subtraction cloning protocol in a model cell system (FDCP-Mix) with many characteristics of normal hematopoiesis. We present here a novel group of 29 validated Myb family target genes of diverse functions. Published online 20 December 2004.
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