期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 201, 期 4, 页码 489-492出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20050179
关键词
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The mechanism by which the ligand occupancy state of the T cell receptor complex is converted into intracellular signaling information has been a controversial topic. Although the majority of structural studies argue against a conformational change, recent studies support the possibility for such a change within the CD3 components of the TCR complex. In this commentary, the evidence for TCR conformational change is reviewed and potential mechanisms for its initiation are explored.
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