期刊
JOURNAL OF NEUROSCIENCE
卷 25, 期 8, 页码 2138-2145出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3530-04.2005
关键词
cytoskeleton; memory; LTP; Morris water maze; fear conditioning; dendritic spines
资金
- NHLBI NIH HHS [R01 HL075714, HL75714] Funding Source: Medline
- NIDA NIH HHS [K02 DA000436, R01 DA014241, DA14331, R37 DA014241, K23 DA014331, DA00436] Funding Source: Medline
- NIDDK NIH HHS [DK55005, R01 DK055005] Funding Source: Medline
- NIMH NIH HHS [R01 MH059800, MH59800] Funding Source: Medline
The adducin family of proteins interacts with the actin cytoskeleton and the plasma membrane in a calcium- and cAMP-dependent manner. Thus, adducins may be involved in changes in cytoskeletal organization resulting from synaptic stimulation. beta-Adducin knock-out mice were examined in physiological and behavioral paradigms related to synaptic plasticity to elucidate the role the adducin family plays in processes underlying learning and memory. In situ hybridization for alpha- and beta-adducin demonstrates that these mRNAs are found throughout the brain, with high levels of expression in the hippocampus. Schaffer collateral-CA1 tetanic long-term potentiation decayed rapidly in acute hippocampal slices from beta-adducin knock-out mice, although baseline spine morphology and postsynaptic density were normal. Interestingly, the input-output relationship was significantly increased in hippocampal slices from beta-adducin knock-out mice. Furthermore, beta-adducin knock-out mice were impaired in performance of fear conditioning and the water maze paradigm. The current results indicate that beta-adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory.
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