期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 48, 期 4, 页码 901-904出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm049167j
关键词
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We have identified a small interfering RNA (siRNA) motif, consisting entirely of 2'-O-methyl and 2'-fluoro nucleotides, that displays enhanced plasma stability and increased in vitro potency. At one site, this motif showed remarkable >500-fold improvement in potency over the unmodified siRNA. This marks the first report of such a potent fully modified motif, which may represent a useful design for therapeutic oligonucleotides.
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