期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2005, 期 5, 页码 817-821出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200400685
关键词
multicomponent reactions; heterocycles; cyclization; amines; strecker reaction
Reactions between 2-formylbenzoic acid, various anilines and HCN result in the formation of 3-amino-4-(arylamino)-1H-isochromen-1-ones in high yield. The mechanism of this three-component condensation involves the intermediate formation of an alpha-aminonitrile and subsequent cyclizationthrough nucleophilic attack of the ortho-carboxylate at the nitrile carbon. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).
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