期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 57, 期 4, 页码 547-558出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2004.10.009
关键词
HIV-1 tat; oligoarginine; penetratin; cell permeable peptide; protein transduction; drug delivery
The intracellular delivery of proteins and other bioactive molecules using membrane-permeable carrier peptide vectors opens the possibility of establishing novel methods of elucidating and controlling cell functions with therapeutic potentials. One of the most typical peptide vectors is a short, arginine-rich peptide segment derived from the human immunodeficiency virus (HIV)-1 Tat protein. We have shown that not only the Tat peptide, but also various arginine-rich oligopeptides possess very similar characteristics in translocation and abilities as a delivery vector. This review summarizes the structures of these peptide vectors, especially the Tat and other arginine-rich peptides, and the current understanding of their internalization mechanisms. (c) 2004 Elsevier B.V All rights reserved.
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