期刊
LASERS IN SURGERY AND MEDICINE
卷 36, 期 3, 页码 171-185出版社
WILEY
DOI: 10.1002/lsm.20143
关键词
astrocytes; corticospinal tract; footprint analysis; low power laser irradiation; macrophage; microglia; photobiomodulation; rat; retrograde and anterograde tract tracing
Background and Objectives: Photobiomodulation (PBM) has been proposed as a potential therapy for spinal cord injury (SCI). We aimed to demonstrate that 810 nm light can penetrate deep into the body and promote neuronal regeneration and functional recovery. Study Design/Materials and Methods: Adult rats underwent a T9 dorsal hemisection, followed by treatment with an 810 nm, 150 mW diode laser (dosage = 1,589 J/cm(2)). Axonal regeneration and functional recovery were assessed using single and double label tract tracing and various locomotor tasks. The immune response within the spinal cord was also assessed. Results: PBM, with 6% power penetration to the spinal cord depth, significantly increased axonal number and distance of regrowth (P < 0.001). PBM also returned aspects of function to baseline levels and significantly suppressed immune cell activation and cytokine/chemokine expression. Conclusion: Our results demonstrate that light, delivered transcutaneously, improves recovery after injury and suggests that light will be a useful treatment for human SCI.
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