Synthesis of quinazolines over recyclable Fe3O4@SiO2-PrNH2-Fe3+ nanoparticles: A green, efficient, and solvent-free protocol

A practical and efficient method is developed for efficient synthesis of quinazoline derivatives through condensation reaction of 2-aminoaryl ketone, an aldehyde, and ammonium acetate, over magnetic Fe3O4@SiO2-PrNH2-Fe3+ NPs as a recyclable nanocatalyst, under solvent-free conditions. The as-prepared nanocatalyst was characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM). Mild conditions, easy work up, high purity of the products, recyclability, readily availability, nontoxicity, economical, and environmental-friendly nature of the iron catalyst are the attractive features of this methodology.