期刊
FITOTERAPIA
卷 76, 期 2, 页码 194-203出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2004.11.010
关键词
Indonesian medicinal plants; free radical; NO
Traditional Indonesian medicinal plants were screened for their inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and for the antioxidant activity through the evaluation of free radical scavenging effect and reducing power. The results of screening indicated that 50 methanolic extracts inhibited (> 50%) lipopolysaccharides (LPS)-induced NO release from RAW264.7 cells at 50 mu g/ml, with 18 having greater than 100% inhibition. At 200 mu g/ml, 61 methanol extracts exhibited inhibitory activity (> 50%), with 45 showing greater than 100% inhibition. In addition, the free radical scavenging effects of 6 methanolic extracts were found to be more than 50% for extract concentration of 0.5 mu g/ml. The results indicate that the extracts contain active compounds that inhibit NO release and scavenge free radical. (c) 2004 Elsevier B.V. All rights reserved.
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