Pd-catalyzed ligand-free desulfitative Heck reaction with arenesulfinic acid salts under air

Palladium-catalyzed cross-coupling reactions of various aryl sulfinic acid salts with a wide variety of vinyl substrates have been achieved in good to excellent yields under simple aerobic conditions at 70 degrees C with the assistance of Cu(II) salts. The reaction can be accelerated by the combination of DMSO with THF. The reported MatsudaHeck type coupling reactions are tolerant to the common functional groups, making these transformations as attractive alternatives to the traditional cross-coupling approaches. Copyright (c) 2013 John Wiley & Sons, Ltd.