期刊
PLANTA MEDICA
卷 71, 期 3, 页码 254-260出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-837841
关键词
Bituminaria mosisiana; fabaceae; pterocarpans; isoflavones; cytotoxicity; necrosis
Using cytotoxicity against KB cancer cells as a lead, bioguided-fractionation of the petroleum ether and ethyl acetate extracts of Bituminaria morisiana leaves led to the isolation of two new pterocarpans, namely 3,9-dihydroxy-4-(3,3-dimethylallyl) [6aR, 11aR]-pterocarpan, 3-hydroxy-4-(3,3-dimethylallyl)-4 '',5 ''-dehydropyrano[8,9:2 '',3 ''][6aR,11aR]-pterocarpan and one new isoflavone identified as 4 ',5 ''-dihydroxy-6 ''-methoxy-4 '',4 ''-dimethyl-4 '',5 ''-dihydro-6 '' H-pyrano[2 '',3 '':7,8]-isoflavone. Moreover, two known pterocarpans, erybraedin C and bitucarpin A, three known isoflavones, daidzein, 8-prenyldaidzein and bidwillon C, one known furocoumarin, pseudoisopsoralen and one known coumestan, coumestrol were isolated. The structures of the isolated compounds were established by means of 1D and 2D NMR spectroscopy, as well as mass spectrometry. Further cytotoxicity tests against cells related to the immune system (Jurkat T, Mono-Mac-6 and polymorphonuclear cells) showed a moderate activity of the known pterocarpan erybraedin C against all cell lines used (IC50 values between 17.6 - 28.8 mu M). In addition, erybraedin C was found to induce necrosis in leukaemia Jurkat T cells.
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