期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 100, 期 -, 页码 105-106出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762005000900017
关键词
antinociception; blood pressure; hemopressin
Hemopressin (PVNFKFLSH), a novel bioactive peptide derived from the alpha(1)-chain of hemoglobin, was originally isolated from rat brain homogenates. Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE). Hemopressin also exerts an antinociceptive action in experimental inflammatory hyperalgesia induced by carrageenin or bradykinin via a mechanism that is independent of opioids. These findings suggest that this peptide may have important regulatory physiological actions in vivo.
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