期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 115, 期 3, 页码 572-583出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200524283
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In humans, the biological limitations to cardiac regenerative growth create both a clinical imperative - to offset cell death in acute ischemic injury and chronic heart failure - and a clinical opportunity; that is, for using cells, genes, and proteins to rescue cardiac muscle cell number or in other ways promote more efficacious cardiac repair. Recent experimental studies and early-phase clinical trials lend credence to the visionary goal of enhancing cardiac repair as an achievable therapeutic target.
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