期刊
NATURE IMMUNOLOGY
卷 6, 期 3, 页码 261-270出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1168
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- NCI NIH HHS [CA47752] Funding Source: Medline
- NIAID NIH HHS [AI44959] Funding Source: Medline
Actin reorganization at the immunological synapse is required for the amplification and generation of a functional immune response. Using small interfering RNA, we show here that dynamin 2 (Dyn2), a large GTPase involved in receptor-mediated internalization, did not alter antibody-mediated T cell receptor internalization but considerably affected T cell receptor-stimulated T cell activation by regulating multiple biochemical signaling pathways and the accumulation of F-actin at the immunological synapse. Moreover, Dyn2 interacted directly with the Rho family guanine nucleotide exchange factor Vav1, and this interaction was required for T cell activation. These data identify a functionally important interaction between Dyn2 and Vav1 that regulates actin reorganization and multiple signaling pathways in T lymphocytes.
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