期刊
APPLIED RADIATION AND ISOTOPES
卷 62, 期 3, 页码 383-387出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2004.06.013
关键词
targeted alpha therapy; Actinium-225; Radium-226; cyclotron; radioisotope production
The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. Proton energies were varied from 8.8 to 24.8 MeV and cross-sections were determined by radiochemical analysis of reaction yields. Maximum yields were reached at incident proton energies of 16.8. MeV. Radiochemical separation of Ac-225 from the irradiated target yielded a product suitable for targeted alpha therapy of cancer. (C) 2004 Elsevier Ltd. All rights reserved.
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