期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 13, 期 5, 页码 1783-1789出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.11.060
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资金
- NCRR NIH HHS [P41RR0954] Funding Source: Medline
- NHLBI NIH HHS [R01 HL069975] Funding Source: Medline
The synthesis of per-sulfated flavonoids, organic compounds with multiple sulfate groups, is challenging. We present here a two-step synthesis of fully sulfated flavonoids in high overall yields using the 2,2,2-trichloroethyl moiety as a protecting group. The two-step synthesis results in exclusive formation of the per-sulfated product in contrast to common sulfating agents that yield differentially sulfated mixture of compounds. Most per-sulfated flavonoids studied are activators of antithrombin for accelerated inhibition of factor Xa, a key enzyme of the blood coagulation cascade. As a group the per-sulfated flavonoids possess a range of factor Xa inhibition potential. (C) 2004 Elsevier Ltd. All rights reserved.
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