期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 53, 期 3, 页码 337-339出版社
SAGE PUBLICATIONS LTD
DOI: 10.1369/jhc.4B6426.2005
关键词
trophoblast cells; prenatal diagnosis; cell sorting; in vitro culture; fluorescence in situ hybridization
类别
Prenatal diagnosis based on rare fetal cells in maternal blood is currently not a feasible option. An effort was made to improve cell yields by targeting trophoblast cells. After sorting, the HLA-G-positive cell fraction was analyzed directly or after culture. In situ hybridization technology was applied to prove fetal cell source in samples from women carrying a male fetus and to predict gender in samples without previous knowledge of fetal sex. In vitro culture led to a significant increase in fetal cells and accurate gender prediction in 93% of these samples. This approach might be useful for non-invasive prenatal diagnosis.
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