期刊
CELL CYCLE
卷 4, 期 3, 页码 397-399出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.4.3.1559
关键词
poly(ADP-ribose); PARP; DNA damage; apoptosis; embryo development; gene targeting
类别
资金
- NINDS NIH HHS [NS39148] Funding Source: Medline
Unlike poly(ADP-ribose) polymerase-1 (PARP-1), poly(ADP-ribose) glycohydrolase ( PARG) has long been a difficult protein to study. However, the complete absence of PARG activity was recently characterized in mice via disruption of the murine PARG gene. As expected, PARG is critical for the maintenance of steady-state poly(ADP-ribose) levels. But surprisingly, the disruption of PARG led to embryonic lethality and increased susceptibility to mild cell stress. Therefore, the protective role of PARG and its involvement in development indicate that these roads to viability go through PARG.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据