期刊
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
卷 77, 期 1, 页码 103-111出版社
ACAD BRASILEIRA DE CIENCIAS
DOI: 10.1590/S0001-37652005000100008
关键词
food ingestion; serotonergic system; dorsal raphe nucleus; electrolytic lesion; para-chlorophenylalanine; obesity
The role of serotonergic system in the feeding behavior was appraised by electrolytic lesions in the dorsal raphe nucleus (DRN) and administration of para-chlorophenylalartine (PCPA. 3 mg/5 mul. icv). Chronic evaluations were accomplished through 120 and 360 days in PCPA-injected and DRN-lesioned rats, respectively. Acute food intake was evaluated in fasted rats and submitted to injection of PCPA and hydroxytryptophan (LHTR 30 mg/kg, ip). DRN-lesioned rats exhibited 22-80% increase in food intake up to sixth month. whereas the obesity was evident and sustained by whole period. In PCPA-injected rats was observed an initial increase in the food intake followed by hypophagy from 25th to 30th day and a transitory increase of body weight from 5th to 60th day. In the acute study, the LHTP reverted partially the PCPA-induced increase in food intake of fasted rats suggesting a sustained capacity of decarboxylation of precursor by serotonergric neurons. Slow restoration of the levels of food intake in DRN-lesioned rats reveals a neuroplasticity in the systems that regulate feeding behavior. A plateau on the body weight curve in lesioned rats possibly represents the establishment of a new and higher set point of energetic balance.
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