期刊
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
卷 18, 期 2, 页码 151-161出版社
SPRINGER
DOI: 10.1007/s10827-005-6556-1
关键词
olfactory processing; synchronization; modeling; gap junction; mitral cells
资金
- NIDCD NIH HHS [DC-00086] Funding Source: Medline
- NINDS NIH HHS [NS11613] Funding Source: Medline
One of the first and most important stages of odor processing occurs in the glomerular units of the olfactory bulb and most likely involves mitral cell synchronization. Using a detailed model constrained by a number of experimental findings, we show how the intercellular coupling mediated by intraglomerular gap junctions (GJs) in the tuft dendrites could play a major role in sychronization of mitral cell action potential output in spite of their distal dendritic location. The model suggests that the high input resistance and active properties of the fine tuft dendrites are instrumental in generating local spike synchronization and an efficient forward and backpropagation of action potentials between the tuft and the soma. The model also gives insight into the physiological significance of long primary dendrites in mitral cells, and provides evidence against the use of reduced single compartmental models to investigate network properties of cortical pyramidal neurons.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据