期刊
NEUROBIOLOGY OF AGING
卷 26, 期 3, 页码 293-302出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2004.02.031
关键词
atherosclerosis; cerebrovascular disease; stroke; pathogenic mechanisms; oxidative stress; aging
资金
- NHLBI NIH HHS [HL-067792, HL-56989] Funding Source: Medline
Increasing evidence indicates that several pathogenic mechanisms promoting atherosclerosis are also involved in neurodegenerative diseases, and that insight into the factors determining the susceptibility to, and long-term progression of, atherosclerosis may be of interest for the evolution of diseases such as Alzheimer's. Furthermore, atherosclerosis of intracranial arteries or thromboembolic consequences of atherosclerotic extracranial arteries are responsible for most ischemic events in the brain. Age-related changes of cerebrovascular atherosclerosis, and atherosclerosis in general, may therefore be important for stroke and neurodegenerative diseases affecting the elderly. In the following, pathogenic mechanism involving, increased lipid peroxidation, oxidative stress, inflammation and immune responses, and fetal programming will be discussed in the context of cerebrovascular disease and aging. (C) 2004 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据