期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 100, 期 -, 页码 83-91出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762005000900014
关键词
platelet-activating factor; platelet-activating factor -acethylhydrolase; inflammatory disease; sepsis
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity. Deacetylation induces the formation of the inactive metabolite lyso-PAE This deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH), a calcium independent phospholipase A(2) that also degrades a family of PAF-like oxidized phospholipids with short sn-2 residues. Biochemical and enzymological evaluations revealed that at least three types of PAF-AH exist in mammals, namely the intracellular types I and II and a plasma type. Many observations indicate that plasma PAF AH terminates signals by PAF and oxidized PAF-like lipids and thereby regulates inflammatory responses. In this review, we will focus on the potential of PAF-AH as a modulator of diseases of dysregulated inflammation.
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