期刊
CELL CYCLE
卷 4, 期 3, 页码 449-452出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.4.3.1555
关键词
ARF; p53; RB; PP2A; apoptosis; cell cycle arrest; DNA tumor viruses; polyoma small T-antigen; polyoma middle T-antigen; cancer
类别
资金
- NCI NIH HHS [CA92454] Funding Source: Medline
The small DNA tumor viruses encode proteins that subvert many of the pivotal growth regulatory pathways within the cell to facilitate their own replication. The cell responds to viral infection/proteins by activating the p53 tumor suppressor pathway. Activation of p53 could impair a productive viral infection at many levels, including the inhibition of viral DNA replication and/or the premature death of infected cells. Therefore, DNA viruses encode proteins that inactivate the p53 tumor suppressor pathway. Understanding how DNA viral proteins activate/ inactivate the p53 pathway has provided invaluable insights into tumorigenesis. Recent studies with polyoma virus have identified a viral protein (PyST) that inhibits ARF-mediated activation of p53, and revealed a novel role for PP2A in the regulation of the ARF-p53 tumor suppressor pathway.
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