期刊
JOURNAL OF MEDICINAL FOOD
卷 8, 期 1, 页码 107-109出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2005.8.107
关键词
human immunodeficiency virus-1 protease; protease inhibitor; Prunus sargentii; Rosa family plant; Rosa rugosa; rosamultin
To identify substances with anti-human immunodeficiency virus (HIV) activity from plant sources, 12 extracts of Rosa family plants were screened for their inhibitory effects against HIV-1 protease. Of the extracts tested, the strongest inhibitory effects were observed in the root of Rosa rugosa and the leaves of Prunus sargentii, at a concentration of 100 mu g/mL. Rosamultin isolated from the root of R. rugosa inhibited HIV-1 protease by 53% at a concentration of 100 mu M.
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