期刊
NEUROPHARMACOLOGY
卷 48, 期 3, 页码 426-434出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2004.10.018
关键词
Xenopus laevis; fetal development; ethanol; ascorbic acid
In this study, we established an embryo model to study the effects of ethanol on fetal development. When embryos of Xenopus laevis (the African clawed frog) were exposed to ethanol, the resultant tadpoles had significantly reduced brain sizes (microencephaly) and retarded growth rates. These effects, similar to those observed in human fetal alcohol syndrome (FAS), were dose- and time-dependent. We further showed that the antioxidant ascorbic acid (vitamin C) could inhibit the ethanol-induced reactive oxygen species (ROS) production and NF-kappa B activation and protect the ethanol-treated embryos against microencephaly and growth retardation. These results suggest the involvement of NF-kappa B and oxidative stress in ethanol-mediated developmental defects, and the potential use of ascorbic acid as a new and effective protective a-gent for FAS. (c) 2004 Elsevier Ltd. All rights reserved.
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