期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 55, 期 3, 页码 283-288出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkh546
关键词
MRSA; cSSSI; vancomycin
Infections caused by drug-resistant pathogens are on the rise. Daptomycin, a cyclic lipopeptide with activity against most Gram-positive pathogens, including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus, is a newly US-FDA approved antimicrobial for complicated skin and skin structure infections (cSSSI). Daptomycin has a unique mechanism of action that results in destruction of the membrane potential. The rapid bactericidal activity of daptomycin makes it an attractive antibiotic for serious Gram-positive infections.
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