期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 98, 期 22, 页码 9389-9398出版社
SPRINGER
DOI: 10.1007/s00253-014-6027-6
关键词
Ganoderma formosanum; Polysaccharides; Immunomodulation; Antitumor
资金
- National Science Council [NSC99-2628-B-002-005-MY3]
- Council of Agriculture, Taiwan [98AS-3.1.3-FD-Z1]
- National Health Research Institutes [NHRI-EX97-9724SC]
- National Taiwan University, Taiwan [NTU-CDP-103R7824]
Fungi of the genus Ganoderma are basidiomycetes that have been used as traditional medicine in Asia and have been shown to exhibit various pharmacological activities. We recently found that PS-F2, a polysaccharide fraction purified from the submerged culture broth of Ganoderma formosanum, stimulates the maturation of dendritic cells and primes a T helper 1 (Th1)-polarized adaptive immune response in vivo. In this study, we investigated whether the immune adjuvant function of PS-F2 can stimulate antitumor immune responses in tumor-bearing mice. Continuous intraperitoneal or oral administration of PS-F2 effectively suppressed the growth of colon 26 (C26) adenocarcinoma, B16 melanoma, and sarcoma 180 (S180) tumor cells in mice without adverse effects on the animals' health. PS-F2 did not cause direct cytotoxicity on tumor cells, and it lost the antitumor effect in mice with severe combined immunodeficiency (SCID). CD4(+) T cells, CD8(+) T cells, and serum from PS-F2-treated tumor-bearing mice all exhibited antitumor activities when adoptively transferred to na < ve animals, indicating that PS-F2 treatment stimulates tumor-specific cellular and humoral immune responses. These data demonstrate that continuous administration of G. formosanum polysaccharide PS-F2 can activate host immune responses against ongoing tumor growth, suggesting that PS-F2 can potentially be developed into a preventive/therapeutic agent for cancer immunotherapy.
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