期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 69, 期 3, 页码 620-622出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.69.620
关键词
psoralen and ultraviolet-A irradiation (PUVA); cross-linking; oxidative DNA damage; antioxidant
We examined antioxidants exhibiting no effects on DNA cross-linking, which is the basis of psoralen and ultraviolet-A therapy for skin diseases, and suppressing oxidative DNA damage incidental to the therapy. Epigallocatechin gallate and esculetin effectively suppressed oxidative DNA damage with little effect on the formation of DNA cross-linking. These antioxidants might be useful in suppressing the adverse reaction induced by this therapy.
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