期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 53, 期 3, 页码 381-384出版社
SAGE PUBLICATIONS LTD
DOI: 10.1369/jhc.4B6427.2005
关键词
ancient DNA; Meckel Anatomical Collection; comparative genomic; hybridization; polymerase chain reaction
类别
We present the first data on our comparative genomic hybridization (CGH)based strategy for the analysis of ancient DNA (aDNA) samples extracted from fetuses preserved in the Meckel Anatomical Collection in Halle, Germany. The collection contains numerous differently fixed ancient samples of fetal malformations collected from the middle of the 18th to the early 19th century. The main objective of this study is to establish a standard aDNA extraction and amplification protocol as a prerequisite for successful CGH analyses to detect or exclude chromosomal imbalances possibly causative for the malformations described for the fetuses.
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