期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 98, 期 8, 页码 3753-3758出版社
SPRINGER
DOI: 10.1007/s00253-013-5409-5
关键词
Marine-derived fungus; Aspergillus versicolor; Sterigmatocystin; Staphylococcus aureus; Bacillus subtilis
资金
- National Program on Key Basic Research Project (973 program) [2013CB734000, 2012CB721000]
- National Natural Science Foundation of China [30901849, 81102356, 81261120389, 81102369]
- CAS Pillar Program [XDA04074000]
- Ministry of Science and Technology of China [2011ZX11102-011-11]
- Genzyme
- Sanofi company
During the systematic screening of active compounds from marine-derived fungi, the extract of a strain of Aspergillus versicolor MF359 isolated from a marine sponge of Hymeniacidon perleve was identified for detailed chemical investigation. Three new secondary metabolites, named hemiacetal sterigmatocystin (1), acyl-hemiacetal sterigmatocystin (2), and 5-methoxydihydrosterigmatocystin (3), together with a known compound, aversin (4), were characterized. 1 represents a first structure of sterigmatocystin hemiacetal from nature. The antibacterial activities of these identified compounds were evaluated against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Compound 3 showed activity against S. aureus and B. subtilis with MIC values of 12.5 and 3.125 mu g/mL, respectively.
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