期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 99, 期 3, 页码 1109-1118出版社
SPRINGER
DOI: 10.1007/s00253-014-6298-y
关键词
System metabolic engineering; Modular pathway engineering; Synthetic biology; Genome-scale metabolic model; Spatial engineering
资金
- Enterprise-university-research prospective program, Jiangsu Province [BY2012054]
- 111 Project [111-2-06]
- 973 project [2012CB720806]
Metabolic engineering facilitates the rational development of recombinant bacterial strains for metabolite overproduction. Building on enormous advances in system biology and synthetic biology, novel strategies have been established for multivariate optimization of metabolic networks in ensemble, spatial, and dynamic manners such as modular pathway engineering, compartmentalization metabolic engineering, and metabolic engineering guided by genome-scale metabolic models, in vitro reconstitution, and systems and synthetic biology. Herein, we summarize recent advances in novel metabolic engineering strategies. Combined with advancing kinetic models and synthetic biology tools, more efficient new strategies for improving cellular properties can be established and applied for industrially important biochemical production.
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