期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 97, 期 11, 页码 4737-4747出版社
SPRINGER
DOI: 10.1007/s00253-013-4887-9
关键词
Prokaryotes; Bacteria; Lipoxygenase; Gene alignment; Phylogeny
资金
- Comissio Interdepartamental de Recerca i Tecnologia CIRIT project [2009GR0819]
- Ministerio de Economia y Competitividad (CICYT) of the Ministerio de Educacion y Ciencia [CTQ2010-21183-C02-01, HBP2006-0027]
Lipoxygenases (EC. 1.13.11.12) are a non-heme iron enzymes consisting of one polypeptide chain folded into two domains, the N-terminal domain and the catalytic moiety beta-barrel domain. They catalyze the dioxygenation of 1Z,4Z-pentadiene moieties of polyunsaturated fatty acids obtaining hydroperoxy fatty acids. For years, the presence of lipoxygenases was considered a eukaryotic feature, present in mammals, plants, small marine invertebrates, and fungi, but now, some lipoxygenase sequences have been detected on prokaryotic organisms, changing the idea that lipoxygenases are exclusively a eukaryotic affair. Lipoxygenases are involved in different types of reactions on eukaryote organisms where the biological role and the structural characteristics of these enzymes are well studied. However, these aspects of the bacterial lipoxygenases have not yet been elucidated and are unknown. This revision discusses biochemical aspects, biological applications, and some characteristics of these enzymes and tries to determine the existence of a subfamily of bacterial lipoxygenases in the context of the phylogeny of prokaryotic lipoxygenases, supporting the results of phylogenetic analyzes with the comparison and discussion of structural information of the first prokaryotic lipoxygenase crystallized and other eukaryotic lipoxygenases structures.
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