期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 13, 期 5, 页码 1497-1505出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.12.032
关键词
unnatural flavonoids; flavonoid alkaloids; thiophenyl; flavonoids; chalcones; diketone; flavones; flavonols
Synthesis of nitrogen and sulfur heterocyclic mimics of furanoflavonoids have been achieved for the first time. Synthesized flavonoid alkaloids and thiophenyl flavonoids have been screened for antifungal and antibacterial activities. All the test compounds barring 25 exhibited antifungal activity. The compound 19 was the best and showed comparable MICs to the known compound karanjin. Compounds 5, 12, 14 and 22 also showed comparable MIC to karanjin. (C) 2005 Elsevier Ltd. All rights reserved.
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