期刊
FEMS MICROBIOLOGY LETTERS
卷 244, 期 1, 页码 207-212出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.femsle.2005.01.045
关键词
antifungal; candida; histatin; saliva; histatin degradation; rabbit submandibular gland saliva
类别
Antifungal activity of histatin 3 against two Candida albicans clinical isolates was determined in assays containing rabbit submandibular gland saliva. Histatin 3 inhibited the cell growth and germination of both isolates dose-dependently (10-100 mug ml(-1)) with maximum inhibition occurring after 60 min incubation. Adding fresh histatin 3 after 60 min caused further reduction in the viable cell count. Higher histatin 3 concentrations (50-100 mug ml(-1)) and prolonged exposure to peptide were required to inhibit germination. Histatin 3 was rapidly degraded in rabbit submandibular gland saliva and this may explain why fresh addition of histatin 3 increases candidacidal activity. (C) 2005 Published by Elsevier B.V. on behalf of the Federation of European Microbiological Societies.
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