Diastereoselective formation of α-aminoamides from carbamoylsilanes and aldehyde imines

Diastereoselectivities were determined for the reaction of a series of aldehyde imines with carbamoylsilanes, each containing chiral auxiliaries at nitrogen. A maximum de of 88% was achieved via a matched double differentiation. (C) 2005 Elsevier Ltd. All rights reserved.