β-Turn peptidomimetics incorporating i+1-i+3 residues:: solid phase syntheses and conformational properties

Solid phase syntheses of compounds 1 were developed. These gave the products in high crude purities, with little or no detectable head-to-tail dimer contaminants. NMR and CD data, interfaced with computational simulations, indicate these molecules sample beta-turn conformations in solution. (C) 2005 Elsevier Ltd. All rights reserved.