期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 92, 期 3, 页码 479-497出版社
SPRINGER
DOI: 10.1007/s00253-011-3557-z
关键词
DNA gyrase; DNA topoisomerase; Supercoiling; Quinolones; Aminocoumarins; NBTIs
资金
- BBSRC (UK)
- PBL (UK)
- John Innes Foundation
- EST
- Biotechnology and Biological Sciences Research Council [BBS/E/J/00000201] Funding Source: researchfish
DNA gyrase is a type II topoisomerase that can introduce negative supercoils into DNA at the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher eukaryotes, making it an attractive target for antibacterials. The fluoroquinolones are examples of very successful gyrase-targeted drugs, but the rise in bacterial resistance to these agents means that we not only need to seek new compounds, but also new modes of inhibition of this enzyme. We review known gyrase-specific drugs and toxins and assess the prospects for developing new antibacterials targeted to this enzyme.
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