期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 48, 期 5, 页码 1680-1684出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm049148+
关键词
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Hsp47 is a collagen-specific molecular chaperone whose activity has been implicated in the,pathogenesis of fibrotic diseases. Here, we describe the development of an assay for screening libraries of chemical compounds for inhibitors of Hsp47. A preliminary screen of 2080 compounds identified four that demonstrated inhibitory activity against Hsp47 in vitro, with IC50 values ranging from 3 to 27 muM. Compounds identified through this method may provide the basis for development of novel antifibrotic therapeutics.
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