期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 86, 期 6, 页码 1719-1736出版社
SPRINGER
DOI: 10.1007/s00253-010-2525-3
关键词
Secondary metabolites; Fungi; Polyketide; Nonribosomal peptides
资金
- National Institute of General Medical Sciences [PO1GM084077, R01GM031837]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM084077, R01GM031837] Funding Source: NIH RePORTER
Aspergillus species have the ability to produce a wide range of secondary metabolites including polyketides that are generated by multi-domain polyketide synthases (PKSs). Recent biochemical studies using dissected single or multiple domains from PKSs have provided deep insight into how these PKSs control the structural outcome. Moreover, the recent genome sequencing of several species has greatly facilitated the understanding of the biosynthetic pathways for these secondary metabolites. In this review, we will highlight the current knowledge regarding polyketide biosynthesis in Aspergillus based on the domain architecture of non-reducing, highly reducing, and partially reducing PKSs, and PKS-non-ribosomal peptide synthetases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据