期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 86, 期 6, 页码 1621-1635出版社
SPRINGER
DOI: 10.1007/s00253-010-2531-5
关键词
Escherichia coli; N-acetylneuraminic acid; Neisseria meningitidis; Polysialic acids
资金
- Direccion General de Investigacion [AGL2007-62428]
- Junta de Castilla y Leon [JCyL 32A08]
Polysialic acids (PA) are protective capsular sialohomopolymers present in some bacteria which can invade the mammalian host and cause lethal bacteremia and meningitis. Biosynthesis and translocation of PA to the cell surface are equivalent in different species and bacterial strains which are produced. The diversity in PA structure is derived from the PA linkages and is a consequence of the specific sialyltransferase activities. The monomer acetylation and the polymer length could be important factors in the potential virulence. In vivo PA production is affected by different physical and chemical factors. The temperature of cellular growth strictly regulates PA genesis through a molecular complex and multifactorial mechanism that operate to transcription level.
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